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Differences between two groups were assessed using a one-tailed Students t -test

Key Takeaway: Topical application alone faces bioavailability limitations

The employed authors hold no personal ownership, consultancy roles, or product-specific financial interests, and no commercial entity funded this review

Regarding safety, the majority of reported adverse events were mild to moderate, ranging from 88% to 96%, depending on the specific study group

reuteri or MnLR were washed with HANKs buffer, digested with trypsin, suspended in PBS, and spread on MRS plates at 10 5 dilutions

It is a chronic inflammatory disorder affecting approximately 10% of women of reproductive age, with an estimated 200 million affected individuals worldwide [1]